The Persians focuses on the women from three generations of a wealthy and prestigious Iranian family, the Valiats, whose life paths bifurcated around the time of the Islamic Revolution. While sisters Shirin and Seema left (along with their brother, partners and Seema’s daughter Bita) for the USA, the family’s matriarch Elizabeth stayed behind in their homeland, as did - in more unusual circumstances - Shirin’s then six-year-old daughter Niaz.

In the novel, both Khaled and Mustafa are shot at the protest and hospitalised. From this point, they are unable to return to their home country. The book explores the subsequent relationship, and eventual diverging paths, of the two friends, along with a third, the enigmatic author Hosam. The latter is introduced early in the novel as an inspirational figure in Khaled's life, after hearing his poem read out - unusually in lieu of a news broadcast - on the BBC Arabic World Service, by a presenter who would soon after be murdered in London (another event based closely on real events). Khaled later meets Hosam by chance in Paris, before the writer (no longer writing) joins him in London and becomes a lasting friend.